Adolescent Idiopathic Scoliosis
Conditions
Interventions
AIS patients:Purely experimental
Non- AIS patients:Purely experimental
Sponsors
Prince of Wales Hospital, Chinese University of Hong Kong
Eligibility
Sex/Gender
Female
Age
11 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. AIS girls between the ages of 11-18 with newly or retrospectively diagnosed AIS with different curve severity will be recruited; 2. Cobb angle of major curve will be measured from standard standing posterior-anterior radiography of the whole spine; 3. Age-matched nnon-AIS subjects who require orthopaedic bone related reconstructive surgery will be recruited.
Exclusion criteria
Exclusion criteria: AIS subjects with the following features are excluded: (1) congenital scoliosis; (2) neuromuscular scoliosis; (3) scoliosis of metabolic etiology; (4) scoliosis with skeletal dysplasia, or (5) scoliosis with known endocrine and connective tissue abnormalities. For non-AIS subjects, subjects with any known bone metabolic disease, scoliosis, or diseases that could affect the bone metabolism will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a) Maximal Cobb angle. b) Serum VitD and 1,25(OH)2D levels. c) Bone mineral density with DXA. e) Association between outcomes a, b and c.; | — |
Secondary
| Measure | Time frame |
|---|---|
| a) Protein and mRNA expression of key players of Vitamin D pathway in bone biopsies b) Standard bone histomorphometry on bone biopsies c) Effect of CYP27B1 on AIS bone derived primary osteoblast and osteocyte culture models.; | — |
Countries
China
Contacts
Public ContactDr. Yuk Wai LEE
Prince of Wales Hospital, Chinese University of Hong Kong
Outcome results
None listed