Perioperative central nervous system complications
Conditions
Interventions
Dexmedetomidine group:During the operation, dexmedetomidine was given continuous infusion according to the weight, and the infusion was stopped 30min before the end of the operation.
control group:During the operation, the saline group was given the same amount of saline for the same time, and the infusion method was the same as that of the dexmedetomidine group.
Sponsors
the First Affiliated Hospital,Medical School of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntary subjects signed informed consent; 2. Age over 65; 3. Non-cardiac, non-transplant and non-neurosurgery patients who are scheduled to undergo general anesthesia; 4. Cardiac function grade I-III (NYHA standard), ASA grade I-III.
Exclusion criteria
Exclusion criteria: 1. MoCA score < 26; 2. History of traumatic brain injury; 3. The assessment cannot be completed in accordance with the requirements of the scale; 4. Those who have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative complications in central nervous system; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of blood-brain barrier injury markers during perioperative period; | — |
Countries
China
Contacts
Public ContactWei Gao
the First Affiliated Hospital, Medical School of Xi'an Jiaotong University
Outcome results
None listed