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The study for palonosetron and dexamethasone injection on Zusanli acupoint on preventive treatment of postoperative nausea and vomiting in adult patients

Study for palonosetron and dexamethasone injection on Zusanli acupoint on preventive treatment of postoperative nausea and vomiting in adult patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900021714
Enrollment
Unknown
Registered
2019-03-05
Start date
2019-03-15
Completion date
Unknown
Last updated
2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative nausea and vomiting

Interventions

Group 1:dexamethasone 5mg injection on Zusanli acupoint
Group 2:palonosteron 0.25mg I.V
Group 3:dexamethasone 5mg injection in gastrocnemiu 3cm adjacent to Zusanli acupoint, plus palonosteron 0.25mg I.V
Group 4:dexamethasone 5mg injecti on Zusanli acupoint, plus palonosteron 0.25mg I.V

Sponsors

The Second Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Female patients undergoing abdominal surgery under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Preoperative history of schizophrenia, epilepsy, Parkinsonism, or myasthenia gravis; 2. Taking monoamine oxidase inhibitors within 2 weeks before the surgery; 3. Inability to communicate in the preoperative period (coma, profound dementia, or language barrier); 4. Brain injury or neurosurgery; 5. Esophageal reflux disease; 6. Severe gastrointestinal disease; 7. Undergoing gasyroinyestinal surgery or history of gastrointestinal surgery; 8. Patients with severe coagulation dysfunction; 9. Patients accepted sedative or antimetric treatment 24 hours before surgery; 10. History of alcohol or analgesia drug abuse; 11. Severe hypertension (systolic blood pressure = 180mmHg, diastolic blood pressure = 110mmHg); 12. Severe hepatic, renal, pulmonary dysfunction; known preoperative left ventricular ejection fraction less than 30%; 13. Women in their pregnancy or lactation; 14. Patients with long-term use of hormone drugs before surgery; 15. Skin infection or other factors influcing Zsnali acupoint injection.

Design outcomes

Primary

MeasureTime frame
postoperative nausea times;Duration of postoperative nausea;postoperative nausea score;postoperative vomiting times;Duration of postoperative vomiting;postopeative vomiting score;—

Secondary

MeasureTime frame
Intestinal exhaust time after extubation;plasma motilin level;Patient's satification for PONV;—

Countries

China

Contacts

Public ContactXiaoli Niu

The Second Affiliated Hospital of Xi'an Jiaotong University

147868794@qq.com+86 18991391520

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026