Internal limiting membrane insertion technique combined with nerve growth factor injection for large macular hole

The study of nerve growth factor injection combined with internal limiting membrane transplantation technique for macular hole

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900021711

Enrollment

Unknown

Registered

2019-03-05

Start date

2016-09-01

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

macular hole

Interventions

Case series:Internal limiting membrane insertion technique combined with nerve growth factor injection

Eligibility

Sex/Gender

All

Age

41 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) The age of the participants ranged from 20 to 80 years, and the BMI was within the normal range (male: 20-25 female: 19-24); (2) Meet the diagnostic criteria of idiopathic macular hole (3) Laboratory examiners: normal blood routine, urine routine, liver and kidney function, and normal electrocardiogram, can tolerate vitrectomy. (4) has good compliance and can be followed up as required.

Exclusion criteria

Exclusion criteria: (1) Under the age of 20 or over 80; (2) With severe retinal detachment or choroidal detachment; (3) Complicated with other internal eye diseases, such as glaucoma, uveitis, severe cataract, optic nerve diseases, etc. (4) Complicated with other complications such as serious cardiovascular, cerebrovascular, liver and hematopoietic diseases; (5) Pregnant or lactating women; (6) Any mental diseases; (5) With cardio-cerebrovascular complications, recent traumatic, surgical or malignant tumors; (6) With acute infection and autoimmune diseases; (7) With other history of posterior segment surgery; (8) allergy to fluorescein sodium skin test, and fluorescein fundus fluorescein angiography is unfeasible.

Design outcomes

Primary

Measure	Time frame
BCVA;OCT images;	—

Countries

China

Contacts

Public ContactWu Miaoqin

Zhejiang Provincal People's Hospital, People's Hospital of Hangzhou Medical College

eyewmq@126.com+86 13906528958

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026