Parkinson's Disease
Conditions
Interventions
Healthy control group:No
tremor-dominant phenotype PD patients group:pramipexole
Sponsors
Department of Neurology, Brain Hospital Affiliated to Nanjing Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: PD patients with tremor-dominant phenotype enrollment criteria: ? The diagnosis of PD fulfilled the UK Parkinson Disease Society Brain Bank Criteria for idiopathic PD; ? Have not taken any anti-Parkinson's disease drugs; ? A clinical resting tremor [defined as Unified Parkinsons Disease Rating Scale(UPDRS) resting tremor score for one arm =2 point and a history of tremor]. Normal control group inclusion criteria: ? No cognitive impairment and dyskinesia; ? Normal nervous system examination; ? MMSE=26,HAMD=7.
Exclusion criteria
Exclusion criteria: ? History of consciousness disorder; ? Family history of hereditary diseases; ? Central nervous system infection, head injury, epilepsy, multiple sclerosis, poisoning metabolic diseases, intracranial tumors, hypothyroidism, diabetes and other physical diseases; ? History of mental illness such as schizophrenia, manic episodes, bipolar disorder, personality change; ? Have a history of alcohol/drug dependence or take medications that improve cognitive awareness; ? Combined with serious heart, liver, kidney, brain and hematopoietic disease; ? MRI scan contraindications such as electronic and metal implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood oxygenation level dependent(BOLD) signal in the brain;DRD3 Ser9Gly gene;blood drug concentration; | — |
Countries
China
Contacts
Public ContactLiu Weiguo
Department of Neurology, Brain Hospital Affiliated to Nanjing Medical University
Outcome results
None listed