Postoperative radiotherapy combined with raltitrexed for gastric cancer patients

Raltitrexed concomitant with radiotherapy as adjuvant treatment for patients with locally advanced gastric cancer: a prospective phase I/II clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900021702

Enrollment

Unknown

Registered

2019-03-05

Start date

2019-04-01

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric Cancer

Interventions

Study Group:Concurrent chemoradiation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Aged less than 70 years, Karnofsky score higher than 80; (2) Postoperative histologically confirmed adenocarcinoma of the stomach; (3)One of the three situations: Received R1 or R2 operation; Received D0 or D1 operation, T3-4 or conformed metastasis in perigastric lymph nodes according to AJCC 8th staging; Received R0 and D2 operation, postoperative histologically conformed metastasis in perigastric lymph nodes; (4) Informed consent signed.

Exclusion criteria

Exclusion criteria: (1) Pregnant or lactating women; (2) Previous malignancy within 5 years; (3) Uncontrolled epilepsy, central nervous system disorders, or history of mental disorders; (4) Severe active heart diseases; (5) History of Organ transplantation who requires immunosuppressive therapy; (6) Severe recurrent active infection existed; (7) Other serious uncontrolled comorbidities.

Design outcomes

Primary

Measure	Time frame
efficacy of concurrent chemoradiation with raltitrexed for the treatment of gastric cancer patients;	—

Secondary

Measure	Time frame
feasibility of concurrent chemoradiation with raltitrexed for the treatment of gastric cancer patients;	—

Countries

China

Contacts

Public ContactLiyuan Zhang

The Second Affiliated Hospital of Soochow University

zhangliyuan126@126.com+86 13862127695

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026