Essential hypertension
Conditions
Interventions
2:Placebo
Sponsors
Xiyuan Hospital CACMS
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 30 to 75 years, male or female; 2. Diagnose with essential hypertension; 3. Grade 1 hypertension with Sitting Diastolic Blood Pressure 90-99mmHg or Systolic Blood Pressure 140-159mmHg; 4. Subjects are volunteered to participate in the trial and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who are known or suspected to be allergic to the test drug and its components; 2. Malignant hypertension, hypertensive emergencies, hypertensive crisis, and hypertensive encephalopathy; 3. Secondary hypertension, including but not limited to the following diseases: unilateral or double renal artery, polycystic kidney disease, hyperaldosteronism, aortic coarctation, Cushing's syndrome, pheochromocytoma; 4. Combined with the following lesions: acute myocardial infarction within 6 months, cerebrovascular accident, transient ischemic attack, large aneurysm or dissection aneurysm, unstable angina, grade II-IV (NYHA classification) history of heart failure, grade II or above atrioventricular block, sick sinus syndrome, bradycardia (heart rate <50 beats/min), or ther malignant or potentially malignant arrhythmias such as atrial fibrillation; 5. Those with serious liver,kidney or blood system diseases or malignant tumors; 6. Those with gastrointestinal lesions or gastrointestinal surgery such as gastrointestinal resection, active gastrointestinal inflammation,ulcers or gastrointestinal bleeding in the past 1 year; 7. Those with a reversed lifestyle or irregular sleep pattern; 8. Woman during pregnancy or lactation or those who have a birth plan in the near future; 9. History of alcohol or drug abuse; 10. Those with neurological or mental disorders who can not or are unwilling to cooperate; 11. Those who are inappropriate to participate in this research; 12. Those who participated in other clinical trials 3 months ago.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour ambulatory blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| PRA;AngII;ALD;HCY; | — |
Countries
China
Contacts
Public ContactXu Hao
Department of Cardiology, Xiyuan Hospital CACMS
Outcome results
None listed