Intracranial atherosclerotic stenosis
Conditions
Interventions
ICAS:None
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. Auxiliary examinations (such as carotid ultrasound, TCD, cranial CTA or MRA) suggest moderate to severe stenosis in MCA (50-99%); 3. Two risk factors for atherosclerosis; 4. Informed consent of patients and their families; 5. (1) Symptomatic intracranial artery stenosis: The first acute ischemic stroke within 14 days occurred in MCA blood supply area confirmed by magnetic resonance DWI; (2) Asymptomatic intracranial artery stenosis: no history of ischemic stroke in the past, or no history of ischemic stroke in MCA blood supply area.
Exclusion criteria
Exclusion criteria: 1. Patients with arrhythmia and other causes who can not complete cardio-cerebral combined CTA examination; 2. Vascular examination revealed moderate or more stenosis or unstable plaque in the lateral extracranial artery of the responsible vessel; 3. The presence of PFO, atrial fibrillation, connective tissue disease, tumors and other patients prone to non-atherosclerotic stroke; 4. Head CT or MRI showed hemorrhage and other lesions (vascular malformations, tumors, brain abscesses); 5. Past history of gastrointestinal ulcer, can not use aspirin and clopidogrel dual anti-platelet aggregation therapy; 6. Liver and kidney function decreased (ALT, AST >3 folders than normal level or creatinine F > 1.5 mg/dl) or CK increased (> 10 folders of normal level); 7. Anaphylaxis or intolerance of aspirin, clopidogrel and statins; 8. Middle cerebral artery occlusion or stenting.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular events;Global atherosclerotic plaque burden; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood biochemical index;calcium score;Degree of vascular stenosis; | — |
Countries
China
Contacts
Public ContactGuo Xiuhai
Xuanwu Hospital, Capital Medical University
Outcome results
None listed