To compare the lung protective effects of intravenous lidocaine and saline on patients at intermediate to high risk of postoperative pulmonary complications: A randomized controlled trial

The lung protective effects of lidocaine on patients at intermediate to high risk of postoperative pulmonary complications: A randomized controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900021677

Enrollment

Unknown

Registered

2019-03-05

Start date

2019-08-08

Completion date

Unknown

Last updated

2020-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Injury

Interventions

lidocaine group:intravenous lidocaine

control group:intravenous saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged =18 years; 2. ASA level II-III; 3. Patients undergoing tracheal intubation under general anesthesia; 4. Patients with high risk of pulmonary complications according to ARISCAT score (> 26); 5. The postoperative hospitalization time is expected to exceed 24h.

Exclusion criteria

Exclusion criteria: 1. BMI > 30; 2. Heart and chest surgery; 3. Preoperative application of ventilator; 4. (1) Adams-Stokes syndrome; (2) Serious heart block, including II or III degree atrioventricular block, double bundle branch block; (3) Severe sinus node dysfunction. 5. Congestive heart failure, liver parenchymal damage (ALT or AST> twice normal), grade C cirrhosis of the child, severe renal failure, and respiratory failure; 6. Have a history of major seizures; 7. Have a history of local anesthetic allergy; 8. Steroid anti-inflammatory drugs were used 24 hours before surgery; 9. Pregnant women; 10. Refuse to participate in the test or sign the informed consent.

Design outcomes

Primary

Measure	Time frame
CC16 protein;	—

Secondary

Measure	Time frame
IL-6,8,10 AND TNF-a;OI;Driving pressure;Incidence of postoperative pulmonary complications;	—

Countries

China

Contacts

Public ContactSu Liu

150040009@qq.com+86 18118309692

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026