Chemotherapy-induced thrombocytopenia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. All cases were diagnosed by histopathology or cytopathology, in line with the "Malignant tumor diagnosis and efficacy criteria" without chemotherapy relative contraindications; and in line with the diagnostic criteria for tumor chemotherapy-induced thrombocytopenia; 2. Patients who receive chemotherapy with gemcitabine or a platinum-containing regimen; 3. Aged between 18-80 years old male and female; 4. The physical condition of the subject is acceptable, Karnofsky > 70 points; 5. The estimated survival time is = 3 months; 6. There is no serious damage to vital organs such as heart, liver, spleen, lung, kidney and bone marrow; 7. No coagulopathy 8. No treatment with rhTPO, rhIL-11, etc. one month before chemotherapy; 9. Platelet count was normal before chemotherapy, platelet (50~75)×10^9/L with or without leukocytes, granulocytes and hemoglobin decreased during chemotherapy; 10. No previous history of drug and food allergies; 11. Subject compliance, agree and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Thrombocytopenia caused by other causes; 2. Pregnancy or intentional pregnancy or lactation women; 3. Those with severe cognitive impairment and mental illness; 4. Consolidation of seriously infected persons; 5. Those with combined blood system diseases and splenomegaly; 6. Secondary liver, spleen and bone metastases; 7. Those who have undergone radiotherapy before treatment; 8. A history of thrombosis in the first three months of treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet count; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time when platelets return to normal;Recurrence rate of thrombocytopenia;Coagulation function;Quality of life; | — |
Countries
China
Contacts
The Third Hospital Affiliated to Beijing University of Chinese Medicine