Lung Cancer, Pulmonary Nodule, Colorectal Cancer, Colorectal Precancerous Lesions
Conditions
Interventions
Group1:Annual LDCT and baseline colonoscopy
Group2:Biennual LDCT and annual FIT,those with positive FIT result will undergo colonoscopy
Sponsors
Cancer Hospital Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 74 Years
Inclusion criteria
Inclusion criteria: Aging 50-74 years old and meeting at least one of the following criteria: 1. Smoking history = 30 pack/years with a subsequent smoking cessation = 15 years; 2. Patients with chronic obstructive pulmonary disorder (COPD), or a history of diffuse interstitial pulmonary fibrosis; 3. Occupational exposure history = 1 year (asbestos, radon, beryllium, uranium, chromium, cadmium, nickel, silicon, diesel exhaust, soot and soot ash); 4. Nonsmoking women: 2nd hand smoking from family members who live together or coworkers in the same room with a smoking history = 30 pack-years and a subsequent smoking cessation = 15 years.
Exclusion criteria
Exclusion criteria: Any of the following conditions: 1. Unable to complete informed consent before entering the research; 2. Metal implants or metal facilities on chest or back (heart stents, cardiac pacemakers, etc); 3. Unable to ensure respiratory function without oxygen supply; 4. History of malignancy or have received cancer therapy before (excluding skin basal cell carcinoma and cervical carcinoma in situ); 5. Having received colonoscopy, fibro-sigmoid colonoscopy, air-barium double contrast radiography or CT simulated colonoscopy in the past 5 years; 6. Having received chest CT examination in past 18 months; 7. Having received surgical resection of lung tissue (including pneumonectomy, lobectomy, sublobectomy, segmentectomy, wedge resection, excluding percutaneous lung centesis or lung biopsy; 8. Lung cancer symptoms:unexplained weight loss of greater than 5 kilograms within the past 12 months or unexplained hemoptysis; 9. Irreversible stage of serious diseases, including severe cardiac-cerebral vascular diseases, kidney failure, severe liver cirrhosis, etc; 10. Presence of any medical reason suggestive of significant mortality risk within 5-years; 11. Unable to raise arms over head while lying on back; 12. Subjects having been included in other cancer screening or prevention research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection rate of suspected lung nodule;Early diagnosis rate of lung cancer;Detection rate of colorectal cancer;Detection rate of colorectal precancerous lesion;Early diagnosis rate of colorectal cancer;Cost-effectiveness; | — |
Countries
China
Contacts
Public ContactNi Li
Cancer Hospital Chinese Academy of Medical Sciences
Outcome results
None listed