Tuberculosis
Conditions
Interventions
High dose 1:4HL2EZLfx/4HL2E
High dose 2:6AmPaHMfxPtoPASZ/12PaHMfxPtoPAS(E)Z
High dose 3:6AmMfxPtoPASL2Z/12MfxPtoPAS(E)L2Z
High dose 4:4HL2EZLFX/4HL2E
standard dose 1:3HREZ/6HRE
standard dose 2:3HREZ/6HRE
Sponsors
Beijing Chest Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) The first retreatment; (2) Sputum Bacteriological Positive (sputum smear positive, or M.tb culture positive, or molecular biology positive); (3) Sputum negative (sputum smear negative and culture negative, see the definition of retreatment of tuberculosis with sputum negative); (4) Chest X-ray indicated tuberculosis with lung lesions; (5) Aged between 18 and 65 years old, male or female; (6) Normal liver and kidney function, as well as normal blood and urine test results; (7) Without Family history of drug-induced deafness; (8) No glaucoma and mental abnormalities, no epileptic seizures, non-pregnant women, no long-term use of immunosuppressive drugs, no complications of diabetes for diabetic TB patients; (9) Voluntary to be subjects and agree to sign the consent form.
Exclusion criteria
Exclusion criteria: (1) With active extra-pulmonary tuberculosis(concomitant tuberculous pleurisy is not excluded); (2) Non-tuberculous mycobacteria; (3) Severe allergy to study drug or any ingredient of it; (4) MDR-TB or XDR-TB in high dose gourp; (5) Isoniazid and/or rifampicin-resistant patients in control group; (6) Suffering from acute and chronic hepatitis, silicosis, moderate to severe anemia or blood disease, pulmonary heart disease, respiratory failure and heart failure, pregnancy, gastric ulcer, long-term alcoholism, cirrhosis, combined with HIV/AIDS, immune diseases, malignant tumors, metabolic diseases, diabetic complications (such as diabetic eye disease, diabetic nephropathy, diabetic peripheral neuritis, etc.), glaucoma and other eye diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cure rate;default rate;relapse rate;treatment completion rate;failure rate; | — |
Countries
China
Contacts
Public ContactGao Weiwei
Beijing Chest Hospital, Capital Medical University
Outcome results
None listed