Gynecologic oncology
Conditions
Interventions
1:calculate the amount of cisplatin with dose level 70mg/m2
2:calculate the amount of cisplatin with dose level 75mg/m2
3:calculate the amount of cisplatin with dose level 80mg/m2
4:calculate the amount of cisplatin with dose level 85mg/m2
Sponsors
Sun Yat-Sen Memorial Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who have the complications to received HIPEC; 2. Age 18 to 65 years; 3. Level of blood creatine is within the normal range before HIPEC,that is 58-96µmol/L; 4. No bone marrow inhibition before HIPEC; 5. Normal hepatic function before HIPEC; 6. Patient consent to participant in the trail and use cisplatin for HIPEC.
Exclusion criteria
Exclusion criteria: 1. Received chemotherapy or radiotherapy before, due to any other reasons; 2. Use cisplatin for any other treatment within 3 weeks after the last cycle of HIPEC; 3. Receive medications that can cause damage to liver or kidney function or lead to bone marrow inhibitation; 4. Allergic to cisplatin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Appearance of dose-limiting toxicity; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood creatine level;evaluation of liver function;degree of bone marrow inhibition;radiological result; | — |
Countries
China
Contacts
Public ContactLi Jing
Sun Yat-Sen Memorial Hospital
Outcome results
None listed