Hip Fractures
Conditions
Interventions
DG:Dexmedetomidine was intravenously administered 0.1 g/kg/h the day before surgery
RG:On the day before the operation, the posterior lumbar plexus block (0.375% ropivacaine, 30ml) was performed by an experienced anesthesiologist under ultrasound guidance and catheterization was perf
RDG:continuous intravenous dexmedetomidine (0.1 g/kg/h) at the same time of continuous lumbar plexus block one day before the surgery, which was maintained during the surgery until 48h after the surge
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Elderly patients with hip fracture who receive elective surgical treatment; 2) Aged 65 years and above; 3) ASA I ~ III; 4) Sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Cmpound injury: multiple fractures, combined with trauma of the head, chest, abdomen, pelvis and other parts other than the hip 2) Contraindications for lumbar plexus block: puncture site infection, peripheral neuropathy, local anesthetic allergy, etc 3) Co-existing neurological diseases: alzheimer's disease, vascular dementia and other diseases that affect the cognitive function of patients 4) There is an allergy to the test drug 5) Have participated in other clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| POD; | — |
Secondary
| Measure | Time frame |
|---|---|
| type and severity of POD;postoperative pain;postoperative inflammatory biomarkers;postoperative complications;drug use;mortality;quality of life; | — |
Countries
China
Contacts
Public ContactJinBao LI
Shanghai General Hospital
Outcome results
None listed