Ischemia-reperfusion of liver
Conditions
Interventions
Hydrocortisone group:The use of hydrocortisone 100mg before interruption in operation, and intravenous drip of 100mg qd, 100mg qd, 50mg qd, common medicine 3 days after operation.
methylprednisolone group:Use of Methylprednisolone 80mg before interruption, and intravenous drip of 80mg qd, 80mg qd, 40mg qd, common medicine 3 days after operation.
placebo group:Use of normal saline 100ml before interruption, and intravenous drip of normal saline 100ml, common medicine 3 days after operation.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patients know the research process and sign informed consent; 2. HBsAg(+), HCV (-), HBV-DNA<10^4 IU/mL; 3. ALT/AST/ALP/GGT < 1.5 ULN; 4. Child-Class A/B; 5. PCT/CRP/IL-6 were normal; 6. No history of intrahepatic and extrahepatic bile duct stones. No signs of extrahepatic and extrahepatic bile duct stones were seen in ultrasound; 7. Intraoperative total liver inflow occlusion.
Exclusion criteria
Exclusion criteria: 1. Chronic long-term inflammatory stimulation, such as ultrasound found intrahepatic and extrahepatic bile duct stones and renal calculi; 2. Diseases such as diabetes, systemic lupus erythematosus, which affect the immune and metabolic system; 3. Abnormal state of coagulation function, such as acute stage of upper gastrointestinal bleeding and acute stage of cerebral infarction; 4. Active infection, such as: clinical confirmation of upper respiratory tract infection, and active hepatitis B infection (HBV DNA fluorescence quantitative >1.0e+6 iu/ml); 5. Severe decompensated liver function (Child-Class C) and renal decompensation (eGFR<30mL); 6. The time of total liver inflow occlusion was less than 30 minutes or more than 90 minutes; 7. Other factors were considered inappropriate for glucocorticoids after being evaluated by clinicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory factors;Liver function; | — |
Countries
China
Contacts
Public ContactYong Zeng
West China Hospital, Sichuan University
Outcome results
None listed