The feasibility of preserving the vagus nerve in complete dissection of mediastinal lymph nodes during thoracoscopic radical resection of lung cancer

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900021509

Enrollment

Unknown

Registered

2019-02-24

Start date

2019-02-25

Completion date

Unknown

Last updated

2019-03-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

NSCLC

Interventions

The experimental group:preserve the vagus nerve in complete dissection of mediastinal lymph nodes

The control group:not presere the vagus nerve in complete dissection of mediastinal lymph nodes

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Aged 18 to 75 years; 2) Preoperative imaging diagnosis of right bronchogenic carcinoma below the secondary bronchus, requiring single lobectomy 3) Imaging showed that the maximum diameter of the tumor was no more than 5cm(2b) and no distant metastasis was discovered (M=0); 4) No coronary heart disease or diabetes; 5) Anesthesia score (American association of anesthesiologists standard) =2; 6) Cardiopulmonary function is tolerable to lobectomy(EF>50%, FEV1% >50% predicted value, FEV1/FVC > 70% and other important organ functions are basically normal, blood gas analysis PO2=75mmHg, PCO2<45mmHg); 7) Non-smoking patients.

Exclusion criteria

Exclusion criteria: 1) History of cough before surgery; 2) Factors that may cause chronic cough: postnasal drip syndrome, gastroesophageal reflux disease, oral angiotensin converting enzyme inhibitor drugs, tuberculosis, chronic bronchitis, COPD, bronchial asthma; 3) Medical history, surgical history or disease that may lead to increased postoperative drainage: such as a history of tuberculosis and a surgical history in the right thoracic cavity;preoperative pleural effusion showed medium or above amount by B ultrasound;pulmonary infection and so on;or combined with other medical history or clinical manifestations that may cause postoperative airleakage, such as accompanied by diffuse emphysema; 4) Imaging findings that anatomic abnormalities such as ectopic vena cava may cause difficulty in identifying vagus nerve;hilar and mediastinal lymph nodes with calcification or lymph node fusion; 5) Patients with other absolute contraindications for surgery or other types of malignant tumors, menstrual period, pregnancy and other conditions considered unsuitable for enrollment by researchers; 6) Lost of follow-up or other reasons can not be clear whether there is persistent cough.

Design outcomes

Primary

Measure	Time frame
CRP;IL-1;IL-6;IL-8;TNF-a;Blood gas analysis;	—

Secondary

Measure	Time frame
Perioperative complications;cough score;	—

Countries

China

Contacts

Public ContactWang Guangsuo

drwangguangsuo@sina.com+86 13590437796

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026