Recurrent Laryngopharyngeal Carcinoma after radiotherapy
Conditions
Interventions
Group 1:Salvage Surgery
Group 2:PLDR
Sponsors
Sichuan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years male and female; 2. Eastern Cooperative Oncology Group (ECOG) performance status is 0-2; 3. Consciousness is clear and can cooperate with treatment; 4. Recurrent laryngopharyngeal cancer confirmed by pathology; 5. Previous information of surgery and radiotherapy can be obtained, including operation mode, operation scope, total dose of target area, segmentation mode, dose distribution, radiation dose to normal tissue and isodose curve, etc.; 6. With operative indications; 7. With radiotherapy indications; There are measurable solid tumors (efficacy evaluation criteria: RECIST 1.1); 8. Women of childbearing age must be in a non-pregnant state (pregnancy test is negative, menopausal women are considered infertile after 12 months of menopause). Women and men of childbearing age should take effective contraceptive measures during the study period and within 3 months after the end of the study; 9. Absolute neutrophil count (ANC) > 1.0*10^9/L; 10. Platelet (PLT) > 75*10^9/L; 11. Subjects must sign a written informed consent and be willing to participate in and complete the study and follow-up.
Exclusion criteria
Exclusion criteria: 1. Patients who underwent overradiation therapy for the lesion within 3 months before entering this study; 2. History of telangiectatic ataxia or other radiosensitivity reactions in the past; 3. Scleroderma or active connective tissue disease; 4. Severe and uncontrollable infectious diseases; 5. Complications with severe mental illness or psychological disorders, central nervous system disorders, cardiovascular and cerebrovascular complications, epilepsy and other diseases may limit their understanding, implementation and treatment compliance with informed consent; 6. With distant metastasis; 7. With operative contraindications; 8. With radiotherapy contraindication; 9. Researchers believe any other physical condition that increases the risk of radiation-related toxicity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local control rate;OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life; | — |
Countries
China
Contacts
Public ContactZhang Peng
Sichuan Cancer Hospital
Outcome results
None listed