Hypoxic Ischemic Encephalopathy
Conditions
Interventions
Two groups:Mild hypothermia therapy and Clinical routine treatment versus routine treatment
Sponsors
Guangzhou Women and Children's Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Full-term infants and birthweight (> 2500g) have the following conditions at the same time: 1. Evidence of fetal distress (at least 1 item): (1) Acute perinatal events, such as placental abruption or umbilical cord prolapse or severe abnormal variation or delayed deceleration of fetal heart rate; (2) Cord blood pH 16mmol/L; 2. Evidence of neonatal asphyxia (any of the three items): (1) 5 min Apgar score 16 mmol/L within 1 hour after birth; (3) Positive pressure ventilation is required for at least 10 minutes. 3. Evidence of abnormal brain function monitoring in neonates with HIE or aEEG: Among them, abnormal brain function of aEEG: (1) upper boundary voltage 10 uV and lower boundary voltage < 5 uV (moderate abnormality); (3) Seizure.
Exclusion criteria
Exclusion criteria: Severe congenital malformations, especially complex cyanotic congenital heart disease, complex nervous system malformations, such as trisomy 21, 13 or 18 chromosomal abnormalities; severe intracranial hemorrhage; clinical tendency to spontaneous bleeding or PLT < 50 *10*9/l; brain damage caused by other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Near-infrared spectroscopy;aEEG;MRI; | — |
Countries
China
Contacts
Public ContactJia Li
Guangzhou Women and Children's Medical Center
Outcome results
None listed