Rabies
Conditions
Interventions
Test Group:rhRIG+vaccine
Control Group:HRIG+vaccine
Sponsors
Yunnan Center for Diseases Control and Prevention
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18-55 years; 2) Can provide legal identification; 3) Can understand the research procedure, the subject himself signed a written informed consent form; 4) Can participate in all planned follow-ups and be able to follow all research procedures Participate in the visit); 5) Non-pregnant and lactating women of childbearing age; no male or female patients have no birth planning within 6 months and agree to take effective contraceptive measures.
Exclusion criteria
Exclusion criteria: 1) Have used rabies vaccine or rabies immunoglobulin before; 2) Those who have had a history of severe allergies in previous vaccinations and who are known to be allergic to any of the ingredients contained in the test drug/vaccine; 3) According to the investigator's clinical judgment, the subject has clinically significant acute febrileness or Infectious disease within 2 weeks prior to the first dose; 4) After consulting the medical history, found heart, liver, kidney, blood, digestive tract, nervous system, mental abnormalities and metabolic abnormalities, etc.The medical history influence the research evaluation which is judged by the researcher ; 5) Have a history of convulsions, epilepsy, mental and nervous system, or a family history of epilepsy; 6) Other vaccines, antiserum, human immunoglobulin and other products are used within 1 month before the test drug/vaccine Or plan to use during the study; 7) Any research or unregistered product other than the research product is used before the application of the test drug/vaccine Products (drugs, vaccines, biological products or devices), or intended for use during the study within 1 month; 8) Drug abuse, alcohol abuse or drug addicts; 9) Any other circumstances that the investigator believes may affect the evaluation of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neutralizing antibody activity; | — |
Countries
China
Contacts
Public ContactLiu Xiaoqiang
Outcome results
None listed