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A randomized controlled study for agartroban and heparin arteriovenous irrigation for anticoagulation after cardiovascular surgery

A randomized controlled study for agartroban and heparin arteriovenous irrigation for anticoagulation after cardiovascular surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900021397
Enrollment
Unknown
Registered
2019-02-19
Start date
2019-03-01
Completion date
Unknown
Last updated
2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heparin-induced thrombocytopenia

Interventions

Heparin group:10mg of heparin was dissolved in 250ml normal saline for arteriovenous irrigation
Argatroban group :2.5mg of argatroban was dissolved in 250ml normal saline for arteriovenous irrigation

Sponsors

Fuwai Hospital, Chinese Academy of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Low-temperature cardiopulmonary bypass patients treated with intraoperative anticoagulant heparin (400U/kg); 2. Patients undergoing normal temperature surgery (including off pump coronary artery bypass grafting and macrovascular interventional surgery) using half dose of heparin (200U/kg) for anticoagulation; 3. Postoperative arteriovenous irrigation with heparin or agartoiban for anticoagulation.

Exclusion criteria

Exclusion criteria: 1. Preoperative diagnosis of patients with a history of HIT. 2. Patients with severe hepatic insufficiency ( Child-pugh grade C or above ).

Design outcomes

Primary

MeasureTime frame
4T score;PF4 antibody;30-day mortality;—

Countries

China

Contacts

Public ContactCao Fangfang

Fuwai Hospital, Chinese Academy of Medical Sciences

fangfang8451@yeah.net+86 15801201689

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026