Dyslipidemia
Conditions
Interventions
Experimental group:hydrochloric acid small split alkali tablets, oral, 500mg/ time, 2 times/day, morning and evening meal half an hour to take, course of treatment: 12 weeks
Control group: hydrochloric acid small split alkali tablet placebo, oral, 500mg/ time, 2 times/day, morning and evening meal half an hour to take, course of treatment: 12 weeks
Sponsors
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with primary dyslipidemia; 2. LDL-C=4.1 mmol/L and TG=2.3 mmol/L (equivalent to WHO typing IIb); 3. Age 18-65 years old; male or female; 4. Those who have not taken lipid-lowering drugs in the past 1 month; 5. Can adhere to long-term medication; 6. The patient's informed consent and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Recent (within 4 weeks) myocardial infarction, or stenting, or bypass surgery, or stroke; 2. Diabetes, nephrotic syndrome and renal insufficiency; 3. Those with poor hypothyroidism or other endocrine diseases; 4. Those whose liver function is more than 2 times the upper limit of normal value; 5. Those with severe or active liver disease; 6. Any other life-threatening or serious illness that cannot be completed for 12 weeks of treatment so as to affect the results of the evaluation; 7. Allergic persons; 8. Known to be berberine intolerance; 9. Other diseases or psychosis that the investigator believes may limit efficacy evaluation or patient follow-up; 10. Patients who have participated in other drug clinical trials in the past 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LDL-C; | — |
Secondary
| Measure | Time frame |
|---|---|
| TG;TC;HLD-C;hs-CRP;Blood pressure;weight;Bristol Stool Chart;traditional Chinese medicine symptom; | — |
Countries
China
Contacts
Public ContactWu Shengxian
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Outcome results
None listed