craniocerebral injury
Conditions
Interventions
ARC:NO Intervention
n-ARC:NO Intervention
Sponsors
First Hospital of Lanzhou University
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years; 2. Brain injury (including patients with craniocerebral trauma and/or brain surgery); 3. Patients with intracranial and/or pulmonary infections who require anti-infective treatment by ceftriaxone; 4. Patients with central venous catheters and arterial catheters; 5. Serum creatinine is within the normal range or below the lower limit of the normal range; 6. The patient or his legal representative signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combine with cardiac insufficiency; 2. Shortage of treatment funding and estimated to be unable to complete treatment; 3. Serious electrolyte imbalance (such as hyperkalemia) requires CRRT treatment; 4. Need to supplement blood products (especially plasma) >1000mL or more; 5. Coexisting abdominal compartment syndrome; 6. Renal insufficiency (eGFR calculated according to the CG formula 30kg/m2; 11. Hb<70g/L.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| probability of PK/PD target attainment(50%fT>MIC and 100%fT>MIC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Half life (T1/2);Clearance (Cl);Change in urinary clearance of unchanged ceftriaxone; | — |
Countries
china
Contacts
Public ContactJian Liu
Outcome results
None listed