Hematological Disease
Conditions
Interventions
Case Series:polymyxin B treatment
Sponsors
the First Affiliated Hospital, College of Medcine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Diagnosed as hematological diseases, granulocytic deficiency accompanied by fever (oral temperature=38.3 (axillary temperature=38.0) or oral temperature=38.0 (axillary temperature=37.7)persisted for more than 1 h), and fever persisted with broad-spectrum antibiotics; 2) Gram-negative bacillus such as Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii and Pseudomonas aeruginosa were positive in fecal screening or sputum culture or blood culture; 3) Aged over 18 years; 4) Good liver and kidney function: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) and total bilirubin were less than twice the normal upper limit;serum creatinine50ml/min/1.73 m2; 5) Signed the informed consent.
Exclusion criteria
Exclusion criteria: 1) Companied with other malignant tumors; 2) Fever due to non-infectious factors; 3) Pregnant or lactating women; 4) Patients participating in other clinical trials at the same time; 5) The other situations that the researchers consider it is unsuitable to be included in the clincial trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions to polymyxin B; | — |
Countries
China
Contacts
Public ContactTong hongyan
Outcome results
None listed