Diminished ovarian reserve
Conditions
Interventions
Group A (control group):Oral dehydroepiandrosterone
Group B (experimental group):Intravenous infusion of umbilical cord mesenchymal stem cells 50ml
Sponsors
The First People's Hospital of Hefei
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 50 years; 2. Patients with large changes in the basic value of FSH; 3. The FSH/LH ratio is increased by >2 to 3.6; 4. The subject or his or her guardian must sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Disease factors: (1) Patient ovary has had an infection 2. Past medical history: (1) Patients with malignant tumors within the past 5 years or currently; (2) The patient has alcohol or drug abuse in the past 6 months; (3) The patient has any potential or current medically-accepted mental illness (which may affect the assessment of the subject); 3. Infection: (1) Uncontrolled bacterial, fungal or viral infections in patients with severe or severe systemic or local infections, especially pulmonary infections; sepsis, persistent bacteremia or meningitis; active tuberculosis, severe acute hepatitis, or other active infectious diseases (Including hepatitis B, hepatitis A, HIV positive patients); 4. Visceral dysfunction: Significant organ failure: (1) Heart ? Patients with severe cardiac dysfunction, such as left ventricular ejection rate < 50%; patients with dysfunction such as right ventricular failure and arrhythmia; ? the presence of uncontrolled high blood pressure or congestive heart failure, active angina requiring nitrate, myocardial infarction or arrhythmia or heart failure requiring active treatment in the past 6 months; (2) Lung ? Patients with pulmonary hypertension; ? Patients with diffuse alveolar hemorrhage and other progressive lung diseases may need to maintain blood oxygen concentration through a mask or other auxiliary machinery; hypoxemia, oxygen saturation < 90%; ? Respiratory failure with restrictive or obstructive pulmonary disease or ventilator support; (3) Liver ? In patients with severe liver dysfunction, alanine aminotransferase (ALT), total bilirubin is more than 3 times the normal maximum value; ? severe hepatic vein occlusive disease (VOD) or sinus obstruction; (4) Kidney: severe renal insufficiency, creatinine is more than 2 times the normal maximum value; creatinine clearance rate < 30 mL / min; 5. Others (1) Patients with known allergies, such as those who are allergic to human albumin, who are allergic to any pharmaceutical reagents required for surgery; (2) Pregnant women or patients planning to become pregnant, breast-feeding patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Follicle stimulating hormone;Follicle stimulating hormone/luteinizing hormone; | — |
Countries
CHINA
Contacts
Public ContactGao Bin
The First People's Hospital of Hefei
Outcome results
None listed