Primary osteoporosis
Conditions
Interventions
First infusion of zoledronic acid:Zoledronic acid
Second infusion of zoledronic acid: Zoledronic acid
Sponsors
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) elderly women after menopause; 2) Meet the diagnostic criteria for osteoporosis and diagnosed as osteoporosis; 3) indication of zoledronic acid medication; 4) Patients voluntarily participate in the trial, determine informed consent for drug interventions and indicators, are willing to bear the risk of medication and sign informed consent; 5) Can check and feedback according to the plan, and cooperate with the researcher of this topic.
Exclusion criteria
Exclusion criteria: 1) Those who do not meet the inclusion criteria; 2) Those who are allergic to any of the bisphosphonates or pharmaceutical ingredients; 3) People with various endocrine and metabolic diseases that cause secondary osteoporosis (such as hyperparathyroidism, diabetes, and other diseases that seriously affect bone or calcium metabolism; 4) Patients with severe liver and renal insufficiency and long-term glucocorticoid and immunosuppressive therapy 5) The patient has taken drugs that affect bone metabolism within 3 months. 6) patients with hypocalcemia, renal insufficiency and hypercalcemia patients; 7) Patients with malignant tumors; 8) severe liver disease, cirrhosis, severe heart failure, arterial calcification; 9) Clinical trial participants who have participated in other research drugs in the past four weeks; 10) Those who have poor compliance and cannot complete the test according to the research plan; 11) For any reason, the investigator believes that the subject is not suitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone metabolism biochemical markers; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical symptom score (degree of pain, mobility, coldness, grip);Bone density; | — |
Countries
China
Contacts
Public ContactDecai Chen
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University
Outcome results
None listed