idiopathic membranous nephropathy
Conditions
Interventions
Case series:TAC monotherapy
Sponsors
Tianjin Hospital
Eligibility
Sex/Gender
All
Age
35 Years to 72 Years
Inclusion criteria
Inclusion criteria: (1) aged between 18 and 75 years; (2) a biopsy proven IMN (stage I–IV); (3) meet one of the following conditions: urinary protein excretion of =3.5 g/24 h with hypoalbuminemia, or serum albumin of =30 g/L with urinary protein of >2.0 g/24 h. All the above abnormalities lasted at least 3 months without spontaneous remission; (4) initial serum creatinine level of <133µmol/L; (5) no immunosuppressive agents used in the previous 6 months.
Exclusion criteria
Exclusion criteria: (1) secondary membranous nephropathy, such as systemic lupus erythematosus; (2) malignant tumor; (3) infection, such as hepatitis B or C virus infection and tuberculosis; (4) pregnancy or lactating; (5) received corticosteroid and/or immunosuppressive agents in the previous 6 months; (6) coexistence of life-threatening complications, such as heart failure, severe infection or active gastrointestinal bleeding; (7) poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in proteinuria;changes in serum albumin;changes in serum creatinine;changes in serum uric acid;side effects; | — |
Countries
China
Contacts
Public ContactYang Dingwei
Tianjin Hospital
Outcome results
None listed