The perioperative effect of Goal-directed fluid therapy combined with different dose of norepinephrine in elderly patients undergoing spinal surgery: a randomized controlled trial

Perioperative effect of Goal-directed fluid therapy combined with different dose of norepinephrine in elderly patients undergoing spinal surgery: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900021309

Enrollment

Unknown

Registered

2019-02-13

Start date

2019-03-01

Completion date

Unknown

Last updated

2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal surgery diseases

Interventions

N1:Norepinephrine 0.03µg·kg-1·min-1

N2:Norepinephrine 0.06µg·kg-1·min-1

Eligibility

Sex/Gender

All

Age

60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. ASA=III; 2. Aged 65 to 85 years; 3. No limitation for gender; 4. Decompression and internal fixation of lumbar vertebral under general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Inability to comply with the study protocal; 2. Renal dysfunction; 3. Hyperthyreosis; 4. Thromboarteritis obliterans; 5. Peptic ulcer; 6. Hepatic dysfunctio; 7. Ischemic enteritis; 8. Congestive heart failure; 9. Abnormal electrocardiogram; 10. Valvular heart disease, Hypertrophic cardiomyopathy, severe pulmonary disease.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative complications;	—

Secondary

Measure	Time frame
Changes of serum ANP, NT-proBNP and Syndecan-1 levels;Time of intestinal exhaust;Time of oral intake and drinking;Time of hospitalization after operation;Total amount of transfusion during perioperative period;	—

Countries

China

Contacts

Public ContactWu Fan

baobaoisshit@163.com+86 18686096424

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026