FindTrial
Sign In

Study for preventive effect and mechanism of gonadotropin-releasing hormone antagonist and aromatase inhibition on early-onset ovarian hyperstimulation syndrome after oocyte extraction

Study for preventive effect and mechanism of gonadotropin-releasing hormone antagonist and aromatase inhibition on early-onset ovarian hyperstimulation syndrome after oocyte extraction

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900021293
Enrollment
Unknown
Registered
2019-02-12
Start date
2017-05-01
Completion date
Unknown
Last updated
2019-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ovarian hyperstimulation syndrome

Interventions

Experimental Group1:taking letrozole
Experimental Group2:Cetrotide
Controll Group:taking placebo

Sponsors

Shenyang Women's and Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Met at least one of the following criteria: (1) number of oocyte retrieval=20 ; (2) mean number of follicles with a diameter of >14mm was=20; (3) on the day of oocyte retrieval, the ovarian diameter was > 10 cm; (4) E2 leve=5000 pg/ml on the day of hCG administration; (5) presentation of clinical symptoms of OHSS on the day of aspiration. 2. Cancellation of fresh embryo transfer and cryopreservation of the whole embyros after oocyte retrieval

Exclusion criteria

Exclusion criteria: 1. Allergy to letrozole and cetrotide; 2. The presence of hepatic and renal diseases, hypertension, cardiac or pulmonary dysfunction or coagulation disorders; 3. Unwilling to participate in the research

Design outcomes

Primary

MeasureTime frame
OHSS;—

Secondary

MeasureTime frame
Estradiol;Luteinizing hormone;follicle-stimulating hormone;follicle-stimulating hormone;Routine blood test;—

Countries

China

Contacts

Public ContactCheng Zhao-Xia

Shenyang Women's and Children's Hospital

Syfyczx1974@126.com+86 13940090114

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026