Refractory Obstructive Meibomian Gland Dysfunction
Conditions
Interventions
Group 1:Intraductal Meibomian Gland Probing
Group 2:Intense Pulsed Light
Group 3:intraductal meibomian gland probing (MGP) combined intense pulsed light
Sponsors
The Second Affiliated Hospital, Zhejiang University, School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years; 2. Fitzpatrick Skin Type 1-4; 3. Standard patient evaluation of eye dryness (SPEED) questionnaire=6; 4. Meibum grade=24 and more than half of the 15 evaluated meibomian gland orifices in each eyelid were obstructed and had no lipid secretion with extrusion; 5. Breakup time of tear film (TBUT) =5s; 6. Schirmer test >5s; 7. Meibo-Scan (OCULUS) showed the atrophy area of meibomian gland in both upper and lower eyelids less than 1/3 of the total area; 8. Did not have symptom relief with conservative treatment (eyelid warming, massage and artificial tears) for at least 1 year before study treatment; 9. Sign informed consent.
Exclusion criteria
Exclusion criteria: Patients with history of corneal contact lens, mite blepharitis, acute eye inflammation or infection and apparent eyelid margin scar as well as patients using lacrimal plug or receiving LASIK were excluded from our study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standard Patient Evaluation of Eye Dryness score;Tear break-up time (TBUT);Corneal fluorescein staining (CFS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Lid margin finding results;Meibum grade; | — |
Countries
China
Contacts
Public ContactJin Xiuming
Eye Center, Affiliated Second Hospital, School of Medicine, Zhejiang University
Outcome results
None listed