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Comparison of the analgesic effect of brachial plexus block by programmed intermittent infusion of dexmedetomidine and ropivacaine at different concentrations in postoperative analgesia of elbow joint surgery: a randomized controlled trial

Comparison of the analgesic effect of brachial plexus block by programmed intermittent infusion of dexmedetomidine and ropivacaine at different concentrations in postoperative analgesia of elbow joint surgery: a randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900021265
Enrollment
Unknown
Registered
2019-02-06
Start date
2019-02-06
Completion date
Unknown
Last updated
2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elbow surgery

Interventions

Group A:Formula of analgesic pump: 0.5ug/ml dexmedetomidine (DEX) +0.2% ropilocaine (Rop), volume 400 ml, fixation rate 5mL/h, automatic control 3 ml, interval 20min
Group B:Formula of analgesic pump: 0.75ug/ml dexmedetomidine (DEX) +0.2% ropilocaine (Rop), volume 400 ml, fixation rate 5mL/h, automatic control 3 ml, interval 20min
Group C:Formula of analgesic pump: 1ug/ml dexmedetomidine (DEX) + 0.2% ropilocaine (Rop), volume 400 ml, fixation rate 5mL/h, automatic control 3 ml, interval 20min
Group D:Formula of analgesic pump: 0.3% ropilocaine (Rop), volume 400 ml, fixation rate 5mL/h, automatic control 3 ml, interval 20min

Sponsors

Ningbo Medical Center Li Huili East Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: A total of 100 patients, ASA I or II, aged 18-65 years and weighing 45-75 kg, were selected for elbow joint surgery.

Exclusion criteria

Exclusion criteria: 1. Preoperative patients with poor understanding ability, mental disorders or central nervous system disorders and cannot cooperate; 2. Patients with diabetes mellitus and heart disease; 3. Patients with clotting dysfunction, puncture site infection, progressive or aggravated nervous system disease or other nerve block contraindications; 4. Aallergic to local anesthetics and Dex; 5. Pregnant women; 6. Patients taking glucocorticoid for more than 6 months; 7. Those addicted to alcohol or frequently taking sedatives and analgesics.

Design outcomes

Primary

MeasureTime frame
Analgesic indicators ( rest, active and continuous passive motion VAS pain score, number of analgesic pump compressions / effective compressions, intravenous paracoxib dose).;Movement indicators ( the elbow flexion Angle of patients in each group at 24h, 48h and 72h after surgery in the state of voluntary movement and continuous passive movement);Incidence of motor block;—

Secondary

MeasureTime frame
Adverse reactions ( hemodynamic indicators, respiratory depression, nausea, vomiting, dizziness, local anesthetic poisoning);—

Countries

China

Contacts

Public ContactZhou LongYuan

Ningbo Medical Center Li Huili East Hospital

396919647@qq.com+86 15867212308

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026