Perioperative Neurocognitive Disorders
Conditions
Interventions
Experimental group:Postoperative intravenous analgesia with dexmedetomidine 5µg/kg + Sufentanil 2 ug/kg + N.S. to 100 ml
Control group:Sufentanil 2 ug/kg + N.S. to 100 ml
Sponsors
Shunde Hospital of Southern Medical University(The First People's Hospital of Shunde)
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Sign the informed consent; 2. Elderly patients undergoing abdominal surgery under general anesthesia with tracheal intubation (The operation is expected to take 2-5 hours); 3. Aged 65 to 80 years; 4. Primary school and above; 5. BMI 18-25kg/m2; 6. ASA physical status I to III; 7. Mini-mental State Examination (MMSE)>27.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in the study; 2. Patients who had a concurrent diagnosis or past medical history of schizophrenia or other psychotic disorder, epilepsy, Parkinson's Disease or myasthenia gravis; 3. Mini-mental State Examination (MMSE)<27; 4. Sleep apnea syndrome; 5. Patients who had a past medical history of using other sedatives; 6. Severe audio-visual dysfunctionunable to communicate; 7. Sick sinus syndromesevere ,severe sinus bradycardia (< 50 beats per minute), or second-degree or above; 8. Atrioventricular block without pacemaker; 9. Cardiac insufficiency or Severe hepatic dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality;Occurrence of Perioperative Neurocognitive Disorders; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative length of stay;Serum S100-beta protein;IL-6;TNF-a;Levels of morning urine melatonin; | — |
Countries
China
Contacts
Public ContactYiwen Zhang
Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde)
Outcome results
None listed