cirrhosis with variceal bleeding
Conditions
Interventions
Group 1:combination of NSBB and endoscopic treatment
Sponsors
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. cirrhosis with no response of NSBB for secondary prevention; 2. Aged 18-75 years old; 3. diagnosis with cirrhosis (based on a liver biopsy or on clear clinical data with compatible findings upon imaging); 4. presence of esophageal varices or gastric varices by a recent upper endoscopy procedure; 5. History of esophageal varices bleeding; 6. provision of informed consent before participating in the study.
Exclusion criteria
Exclusion criteria: 1. baseline HVPG <12 mmHg; 2. end-stage cirrhosis (with refractory ascites, hepatorenal syndrome and a score=10 in the Child-Pugh scoring system); 3. contraindications to NSBBs (asthma, severe chronic obstructive lung disease, sinus bradycardia, II-III degree atrioventricular block); 4. taking drugs that affect the metabolism and absorption of non-selective beta blockers in the body at the same time; 5. also use other drugs that reduce portal pressure; 6. liver cancer, portal vein thrombosis or cavernous transformation of the portal vein; 7. Severe heart, lung, liver, kidney dysfunction, or severe bleeding disorders or local/systemic infections, hypothyroidism, Raynaud's syndrome, peripheral vascular disease, etc.; 8. Women who are planning to become pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rebileeding Rate; | — |
Countries
China
Contacts
Public ContactYuZheng Zhuge
Gulou Hospital Affiliated to Nanjing University Medical College
Outcome results
None listed