Awake Intubation
Conditions
Interventions
Venous control group:Dexmeditomidine 1µg/kg 10min iv,Fentanyl 1µg/kg iv
Venous group 1:Dexmeditomidine 1µg/kg 10min iv,Fentanyl 1µg/kg iv,ketamine 0.1mg/kg iv
venous group 2:Dexmeditomidine 1µg/kg 10min iv,Fentanyl 1µg/kg iv,ketamine 0.2mg/kg iv
venous group 3:Dexmeditomidine 1µg/kg 10min iv,Fentanyl 1µg/kg iv,ketamine 0.3mg/kg iv
Transnasal control group:Dexmeditomidine 1.5µg/kg, Fentanyl 1.4µg/kg transnasal
transnasal group 1:Dexmeditomidine 1µg/kg, Fentanyl 1µg/kg, ketamine 0.2mg/kg transnasal
transnasal group 2:Dexmeditomidine 1µg/kg, Fentanyl 1µg/kg, ketamine 0.4mg/kg transnasal
transnasal group 3:Dexmeditomidine 1µg/kg, Fentanyl 1µg/kg, ketamine 0.6mg/kg transnasal
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medidcine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Aged 18-60 years old patients undergoing fiberoptic bronchoscopy guided awake tracheal intubation, American Association of Anesthesiologists (ASA) grade I-II, organs function is normal or compensatory sound.
Exclusion criteria
Exclusion criteria: Patients with sinus bradycardia, atrioventricular block, hypertension, coronary heart disease, asthma, intracranial hypertension, hyperthyroidism or mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| global efficiency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Motor Activity Assessment Scale;The Obsever’s Assessment of Assessment of Alertness/Sedation Scale;Visual Analogue Scale/Score;bispectral index,BIS;blood concentration;liver function;renal function; | — |
Countries
China
Contacts
Public ContactHong Jiang
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed