Colorectal cancer
Conditions
Interventions
Dexmedetomidine group:Patients were injected with 0.6 µg/kg/h dexmedetomidine by intravenous injection after anesthesia induction to 30 min before the end of the surgery.
Epidural blockade group:The epidural blockade was conducted by epidural injection of 2% lidocaine
Combined group:Patients were treated with both dexmedetomidine and epidural blockade as described above
Control group:Patients were injected with 0.6 µg/kg/h of normal saline
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Preoperative diagnosis of colorectal cancer, radical resection of colorectal cancer; 2. ASA classification I~II; 3. Aged over 65 years; 4. The principal investigator and assistant investigator can understand and adhere to the research program, communicate with each other, and agree to sign the informed consent when screening and evaluating before operation.
Exclusion criteria
Exclusion criteria: 1. Patients undergoing laparoscopic surgery; 2. Preoperative patients with severe heart disease (NYHA cardiac function grade > grade 3), severe renal insufficiency (serum creatinine > 1.8 mg/dL (159.1 micromol/L) or renal function replacement therapy), and severe hepatic insufficiency (improved Child-Pugh grade C); 3. Patients with distant metastasis; 4. Patients allergic to lidocaine, ropivacaine, sufentanil, rocuronium and other anesthetics; 5. Patients with other gastrointestinal diseases, such as esophageal reflux or peptic ulcer; 6. Patients taking other analgesics, sedatives or antidepressants within 2 weeks before the study; 7. Preoperative patients with coagulation dysfunction; 8. Patients with contraindication of epidural puncture; 9. Patients with mental illness or cognitive impairment, poor coordination and compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE scores at different time points after surgery;Ramsay scores at different time points after surgery;VAS scores at different time points after surgery;PCIA pressing times; | — |
Secondary
| Measure | Time frame |
|---|---|
| ??3???????;Hospital stay time;First anus exhaust time;First out of bed activity time; | — |
Countries
China
Contacts
Public ContactJing Zhong
Outcome results
None listed