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To evaluate the effect of protective pulmonary ventilation strategy on cognitive impairment after general anesthesia

To evaluate the effect of protective pulmonary ventilation strategy on cognitive impairment after general anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900021155
Enrollment
Unknown
Registered
2019-01-30
Start date
2019-03-01
Completion date
Unknown
Last updated
2019-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postperative cognitive impairment

Interventions

Group 1:Standdard treatment
Group 2:Protective pulmonary ventilation

Sponsors

The Third Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 85 Years

Inclusion criteria

Inclusion criteria: Lumbar posterior decompression bone graft fusion and internal fixation,Ages sixty-five to eighty-five,ASA classification I to II, the BMI is nineteen to twenty-four, the score of MMSE is greater or equal to twenty-four.

Exclusion criteria

Exclusion criteria: 1. A history of chronic pain, central nervous and mental illness, use of antidepressants and sedatives, Parkinson's disease, epilepsy, and preoperative hypoxemia, chronic pulmonary disease, and asthma; 2. The operation time more than four hours; 3. Intraoperative blood loss exceed 800mL; 4. The operation is cancelled for various reasons.

Design outcomes

Primary

MeasureTime frame
Oxygen partial pressure;PCO2;Oxygen saturation;Lactic acid;IL-6;IL-8;SP-A;Cognitive function;GFAP;CC16;—

Countries

China

Contacts

Public ContactQiujun Wang

The Third Hospital of Hebei Medical University

13933178001@163.com+86 18533112929

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026