Cerebral small vessel disease
Conditions
Interventions
Experimental group:Conventional drugs and cholinesterase inhibitors + mouse nerve growth factor (mNGF)
Control group:Conventional drugs and cholinesterase inhibitors
Sponsors
The First Affiliated Hospital, Sun Sat-sen University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 50-80 years old; 2. Clinical symptoms of acute CSVD, including TIA or lacunar infarction, and with related lesions on MRI imaging (acute infarction with diameter = 1), white matter lesion (Fazekas > = 2), cerebral microbleeds (number > =1 in deep white matter), enlarged perivascular space(number > = 10 in basal ganglia); 4. Clinical diagnosis of vascular cognitive impairment or dementia, MMSE score =<26; 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Intracranial or extracranial arterial stenosis of > 50% luminal stenosis or prior history of endarterectomy of cerebral large arteries; 2. TOAST classification suggested (very) possible cardioembolic stroke; 3. Large cortical or subcortical infarctsion with diameter > 1.5cm on MRI; White matter lesions caused by other diseases such as multiple sclerosis; Other central nervous system diseases such as cerebral hemorrhage, brain trauma, epilepsy, encephalitis, hydrocephalus or brain tumors; Oher systemic diseases, such as liver and kidney insufficiency, tumor, etc.; 4. History of alcohol intoxication, drug addiction, or mental disease, or severe aphasia; 5. Contraindication for MRI examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ADAS-cog; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE;MoCA scale;digit span test;Activity of Daily Living Scale;Patient Health Questionnaire-9 Score;Hamilton anxiety scale;Hamilton depression scale; | — |
Countries
China
Contacts
Public ContactFan Yuhua
The First Affiliated Hospital, Sun Sat-sen University
Outcome results
None listed