Bipolar Disorder
Conditions
Interventions
First episode, oral lithium carbonate group:oral lithium carbonate therapy
Recurrent, oral lithium carbonate group:Oral lithium carbonate treatment
Recurrent, oral valproic acid group:Oral valproic acid therapy
Sponsors
Zhengzhou Eighth People's Hospital (Zhengzhou Mental Health Center)
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Meet ICD-10 diagnostic criteria for bipolar mania without psychiatric symptoms; 2. Patients with first-episode or recurrence; 3. Female, Aged 18-45 years; 4. Young Mania Rating Scale (YMRS) total score=6, and 17 Hamilton Depression Scale (HAMD-17) total score<7; 5. The patient or family member sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe physical illness, brain organic illness, endocrine and metabolic diseases, serious allergies and substance abusers; 2. Used drugs that affect hormone levels in the last four weeks; 3. Pregnant or lactating women; 4. Patients who used ECT in the last four weeks; 5. Subjects who cannot successfully complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FSH;LH;Prolactin;Progesterone;Estradiol;Testosterone;TSH;TT4;TT3;FT4;FT3;Insulin;Homocysteine;HAMD-17;YMRS;MOAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI;ECG;waistline;liver function test;Renal function test;blood glucose level;serum lipid level;amylase; | — |
Countries
China
Contacts
Public ContactLi Meng
Zhengzhou Eighth People's Hospital (Zhengzhou Mental Health Center)
Outcome results
None listed