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Comparison of norepinephrine, phenylephrine and ephedrine during cesarean section with spinal anesthesia: a randomized controlled trial

Comparison the efficacy and safety of norepinephrine, phenylephrine and ephedrine during cesarean section with spinal anesthesia: a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900021084
Enrollment
Unknown
Registered
2019-01-28
Start date
2018-07-01
Completion date
Unknown
Last updated
2019-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal hypotension during cesarean section

Interventions

group N:4ug/min norepinephrine infusion immediately post spinal anesthesia
group P:50ug/min phenylephrine infusion immediately post spinal anesthesia
group E:4mg/min ephedrien infusion immediately post spinal anesthesia

Sponsors

Obstetrics and Gynecology Hospital Affiliated to Nanjing Medial University
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists (ASA) grade I or II, singleton, non-laboring, scheduled for elective cesarean section with spinal anesthesia.

Exclusion criteria

Exclusion criteria: 1. Known fetal abnormality, suspected fetus compromise; 2. Chronic hypertension, chronic hypertension comorbid with preeclampsia, preeclampsia, diabetes mellitus, cardiovascular or cerebrovascular disease, and maternal baseline SBP lower than 100 mmHg.

Design outcomes

Primary

MeasureTime frame
systolic blood pressure;heart rate;—

Secondary

MeasureTime frame
incidence of hypotension;incidence of hypertension;incidence of bradycardia;incidence of tachycardia;requirement of additional rescue bolus;Apgar score;neonatal blood gas analysis;—

Countries

Chian

Contacts

Public ContactXian Wang

Department of anesthesiology, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medial University

wangxian2002@126.com+86 13770723174

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026