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Radiotherapy concurrent with nab-taxel/DDP in advanced squamous cell esophageal cancer: phase I/II study

Radiotherapy concurrent with nab-taxel/DDP in advanced squamous cell esophageal cancer: phase I/II study

Status
Active, not recruiting
Phases
Phase 2
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900021079
Enrollment
Unknown
Registered
2019-01-27
Start date
2019-02-11
Completion date
Unknown
Last updated
2019-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

squamous cell esopahgeal cancer

Interventions

Case series:concurrent chemoradiotherapy with nab-taxel plus DDP

Sponsors

Sun Yat-sen University Cancer Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Signing written informed consent; 2. Aged 18 to 70 years; 3. histology of esophageal squamous cell carcinoma; 4. Initial diagnosis, never received anti-cancer treatment such as surgery/chemotherapy/radiotherapy/targeted therapy; 5. Diseases measurable according to RECIST standards; 6. PS score 3.0g/dL); 9. Serum AKP is less than twice the normal upper limit (ULN); 10. Total bilirubin 60 ml/min); 12. Absolute neutrophil count (ANC) >2.0 *10^9/L, hemoglobin (Hb) > 9g/dl, platelet (> 90 *10^9/L).

Exclusion criteria

Exclusion criteria: 1. Distant organ metastasis (confirmed or suspected); 2. Previous treatment for esophageal cancer (excluding exploratory surgery); 3. Heart failure, coronary heart disease and myocardial infarction occurred within 6 months prior to enrollment; 4. Esophageal fistula detected by esophagoscopy/esophagography or the risk of esophageal bleeding observed clinically; 5. be allergic to any drug in the study; 6. Pregnancy or lactation; 7. Use of any drug in the study prior to inclusion in the study; 8. Other malignant tumors within five years, except non-melanoma skin cancer; 9. Persons without legal capacity.

Design outcomes

Primary

MeasureTime frame
clinical complete response;

Countries

China

Contacts

Public ContactYonghong Hu

Sun Yat-sen University Cancer Center

huyh@sysucc.org.cn+86 18602009693

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026