constipation in Parkinson's disease
Conditions
Interventions
intervention group:electroacupuncture+usual care
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chineses Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) diagnosis of Parkinsons disease according to the UK Parkinsons Disease Society Brain Bank Clinical Diagnostic Criteria; (2) met the diagnostic criteria of Roman IV diagnostic criteria for functional constipation; (3) aged between 40 and 80 years; (4) the course of PD is >=6 months, and the course of constipation is >=3 months; (5) the number of SBMs per week <3 times; (6) those who are not satisfied with current constipation treatment or who have not yet received constipation treatment; (7) the Hoehn-Yahr (H&Y) stage belongs to 1-4; (8) those who voluntarily participate in the study, receive relevant examinations and treatments, and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) patients with serious cardiovascular and cerebrovascular diseases, hematopoietic diseases, malignant tumors and other serious life-threatening diseases; (2) patients who have been diagnosed as schizophrenia or major depression, or major depression (Mini-mental State Examination(MMSE) :the illiterateeducational level is <14 scores, the primary school educational level is <20 scores, and the secondary school and above educational level is<24 scores); (3) patients with a history of laparotomy?or anorectal surgery (except for hemorrhoid surgery, one year after appendectomy, inguinal hernia repair) that may affect intestinal transit; (4) patients who have been diagnosed with anal tumors, malformations, suspected intestinal obstruction or other organic diseases leading to constipation; (5) patients can not be treated with EA with acupuncture points in this study may because of skin diseases, limb defects, or other condition; (6) patients who have received other clinical trials or acupuncture treatment within 30 days before treatment may affect the results of this study; (7) patients with acute gastrointestinal disease within 2 weeks before treatment; (8) patients taking antidepressants, analgesics, and antihistamines that affect PD symptoms within 2 weeks before treatment; (9) pregnant or lactating women (female patients under 60 years age undergo urine pregnancy test).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the change from baseline in mean spontaneous bowel movements(SBMs) per week according to the stool diary in the weeks 8-9.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change from baseline in mean SBMsper week according to the stool diary (excluding the weeks 8-9);The change from baseline in mean BMsper week according to the stool diary;The change from baseline in mean Bristol Stool Form Scale score according to the stool diary;The change from baseline in mean straining score according to the stool diary;mean frequency and mean dosage of emergency defecation drugs used per week;VAS score;Sections II and III of Unified Parkinson Disease Rating Scale;The time and number of steps required to walk 20 meters; | — |
Countries
China
Contacts
Public ContactHuan-Gan Wu
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed