Myelodysplastic syndrome, Elderly acute myeloid leukemia
Conditions
Interventions
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Myelodysplastic syndrome diagnosed according to the 2008 WHO guidelines, IPSS scores in the intermediate-2/high-risk groups. 2. Elderly acute myeloid leukemia diagnosed according to the 2008 WHO guidelines, namely age = 65 years. 3. Liver function: serum bilirubin = 35 umol/L, AST/ALT below the upper limit of the normal value of 2 times. 4. Renal function: serum creatinine = 150 umol/L. 5. Normal heart function (NYHA 1-2). 6. Informed consent has been signed.
Exclusion criteria
Exclusion criteria: 1. Abnormal liver function: serum bilirubin > 35 umol/L, AST/ALT is greater than the upper limit of the normal value 2 times; 2. Abnormal renal function: serum creatinine > 150 umol/L; 3. Abnormal heart function (NYHA 3-4); 4. There are other organ malignant tumors; 5. Those who are active during tuberculosis; 6. HIV positive; 7. Pregnant or lactating women; 8. Those who are allergic to decitabine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| remission rate;Bone marrow cell morphology;Minimal residual disease (MRD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;coagulation function;blood biochemistry;electrocardiogram; | — |
Countries
China
Contacts
Public ContactLiu Bei
The First Hospital of Lanzhou University
Outcome results
None listed