Infertility
Conditions
Interventions
Group A:Centrotide, 0.125mg/d
Group B (Prednisone):0.25mg/d Cetrotide,and 10mg qd Prednisone is administered orally
Group C (conventional GnRH antagonist protocol):0.25mg/d Centrotide
Sponsors
Ruijin Hospital of Shanghai
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Aged 20 to 35 years; 2. GnRH antagonist protocol is employed for IVF/ICSI and will be followed by fresh embryo transfer; 3. Patients must agree and sign the informed consent and comply with the trial requirements.
Exclusion criteria
Exclusion criteria: 1. Reduced ovarian reserve (criteria: FSH > 15IU/L, bilateral AFCs < 5, AMH < 1.1ng/L); 2. PCOS patients with uncontrolled androgen; 3. Untreated hydrosalpinx; 4. Untreated endometrial polyps; 5. Moderate to severe intrauterine adhesions; 6. Endometriosis, adenomyosis, hysteromyoma (except subserous myoma); 7. Have experienced spontaneous abortion or implantation failure for twice or more; 8. Thyroid dysfunction, immune abnormality and insulin resistance not treated to normal level; 9. There are other internal and surgical diseases that are unsuitable for or have impact on pregnancy; 10. Known drug-related contraindications (e.g. allergy to Cetrotide, or known contraindications for glucocorticoid).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate (number of pregnant cases which are confirmed by ultrasound/ total number of transplanted cases); | — |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical pregnancy rate (number of pregnant cases which are confirmed by blood ß-hCG examination / number of transplanted cases);implantation rate (number of gestational sacs / number of transplanted embryos);early miscarriage rate (number of miscarriage cases / number of pregnant cases confirmed by ultrasound);late miscarriage rate (number of miscarriage cases / number of pregnant cases confirmed by ultrasound);premature birth rate (number of premature births/ number of pregnant cases confirmed by ultrasound);live birth rate (number of deliveries / number of transplantation cycles);mean number of retrieved oocytes;fertilization rate (number of fertilized oocytes / number of retrieved oocytes);available embryo rate (number of D3 available embryos / number of embryos);rate of high quality embryos [number of D3 high quality embryos (=7 score)/ number of embryos];rate of cycle cancelation due to premature ovulation (number of cancelled cycles due to premature ovulation / number of total cycles in the specific group), rate of adverse effect.; | — |
Countries
China
Contacts
Public ContactBufang Xu
Ruijin Hospital of Shanghai
Outcome results
None listed