Gynecologic Malignancy
Conditions
Interventions
Group D1R:transversus abdominis plane block with0.5 µg/kg DEX and ropivacaine
Group D2R:transversus abdominis plane block with 1 µg/kg DEX and ropivacaine
Group D3R:transversus abdominis plane block with 2µg/kg DEX and ropivacaine
Group R:only use ropivacaine for transversus abdominis plane block
Group C:NO TAP block
Sponsors
Hunan Cancer Hospital
Eligibility
Sex/Gender
Female
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: Elective laparotomy gynecological malignant tumor resection patients 1. aged 16-70 years old; 2. ASA I to III; 3. Body mass index below 32kg/m2.
Exclusion criteria
Exclusion criteria: 1. Puncture site infection, hematoma; 2. Postoperative BP< 90/60mmHg,HR<50 times /min; 3. Massive hemorrhage, postoperative coagulation dysfunction. 4. With history of local anesthetic or dexmedetomidine allergy; 5. With coagulation dysfunction and liver and kidney dysfunction; 6. With mental disorder, unable to clearly express pain NRS score.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score;postoperative assumption of opioids;plasma concentration of ropivacaine;plasma concentration of ropivacaine;The interval between the end of TAP block and the first activation of PCIA; | — |
Secondary
| Measure | Time frame |
|---|---|
| vital signs;PONV scores;Ramsay score; | — |
Countries
China
Contacts
Public ContactZeng yuexiang
Department of Anesthesiology, Hu'nan Cancer Hospital
Outcome results
None listed