postoperative delirium
Conditions
Interventions
Group 1:sub-dose dexmedetomidine infusion (<0·2 µg/kg per h )
Sponsors
Tongji Hospital of Tongji University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Postoperative patients with orthopedics older than 60 years old and non-mechanical ventilation
Exclusion criteria
Exclusion criteria: 1. With delirium when admisson to ICU; 2. With serious central nervous system diseases (such as stroke, Parkinson's, dementia, etc.) or severe impairment of cognitive function can not complete the assessment; 3. severe sinus bradycardia (< 50 beats per minute), or second-degree or above atrioventricular block without pacemaker; 4. Alcohol or benzodiazepine withdrawal; 5. Severe hepatic dysfunction (Child-Pugh class C); 6. Severe renal dysfunction (requirement of renal replacement therapy); 7. Hemodynamic instability or need to use vasopressors when entering the ICU; 8. Low likelihood of survival for more than 24 h; 9. Refused to participate the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| the duration of delirium;Length of stay in ICU or hospital after surgery;??????a;CRP;IL-1;IL-6;Postoperative Cognitive Dysfunction;Pain intensity;Adverse events;all-cause mortality at 28 days; | — |
Countries
China
Contacts
Public ContactWang Gang
Tongji Hospital of Tongji University
Outcome results
None listed