ICU-acquired weakness
Conditions
Interventions
Group 1:very early bedside cycle exercise
Group 2:early bedside cycle exercise
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. When entering the ICU<24h; 2. The estimated mechanical ventilation time is =48h; 3. When entering the ICU, the RASS sedation assessment score is between -2 and -5; 4. Aged 18 to 80 years; 5. Weight <135 kg (maximum weight of bedside bicycle); 6. Voluntary participants after communicating with the patient's family members; 7. No brain organic lesions; 8. The patient's circulation was stable within 24 hours of ICU, with or without vasoactive drugs to maintain the target blood pressure for at least 2 hours, and the vasoactive drug dose was unchanged; 9. The patient's breathing was stable within 24 hours of ICU, respiratory rate 5-40 beats / min, SPO2=90%; Patients with mechanical ventilation had FiO2=0.6 and PEEP =10cmH2O.
Exclusion criteria
Exclusion criteria: 1. Have primary motor dysfunction or clear neuromuscular diseases, such as myasthenia gravis, Guillain-Barre syndrome, amyotrophic lateral sclerosis, etc.; 2. Lumbar vertebrae, pelvis, lower extremity trauma or surgery; 3. Increased intracranial pressure; 4. Limb defects; 5. Lower extremity arterial catheterization, continuous acceptance of CRRT, IBAP, ECMO; 6. Deep vein thrombosis of the lower extremities; 7. There is active bleeding 8. Having a pacemaker or an implantable defibrillator; 9. Pregnant women; 10. Redness, bleeding, etc. occurred in the measurement points of the lower extremities; 11. Expecting death or performing palliative care; 12. Participate in other research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle strength; | — |
Secondary
| Measure | Time frame |
|---|---|
| muscle mass; | — |
Countries
China
Contacts
Public ContactLong Yun
Outcome results
None listed