Chronic kidney disease
Conditions
Interventions
Gold Standard:Electrocardiogram, echocardiography and cardiac biomarkers.
Index test:1. 
examination: 
homocysteine, 
serum 
superoxide 
dismutase, 
ischemia-modified 
parathyroid 
lipoprotein 
2. 
Sponsors
Tungwah Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years; 2. Ckd-epi formula was used to estimate glomerular filtration rate. According to K/DOQI guidelines, eGFR 59mL/(min·1.73m2) was defined as stage 3a -5 of chronic kidney disease; 3. Primary or combined with diabetes, hyperuricemia and hypertension; 4. Live in Guangdong province for 2 years or more, and be able to cooperate with the follow-up.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with or complicated with acute ischemic diseases in recent 3 months, such as acute coronary syndrome, acute ischemic cerebrovascular disease, peripheral vascular occlusion, and acute mesenteric ischemia; 2. Severe liver failure or heart failure in recent 3 months; 3. Patients with obvious infection in the last 1 month; 4. Patients with acute vasculitis, autoimmune disease or thyroid disease; 5. Suffering from malignant tumors and infectious diseases; 6. Women of childbearing age who do not agree to relevant examinations, or who are pregnant, lactating or unwilling to use birth control during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| brachial-ankle pulse wave velocity;flow mediated dilation;intima-media thickness;coronary calcification score;SEN?SPE?ACC?AUC of ROC; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reaction protein;homocysteine;cardiac troponin;parathyroid hormone;lipoprotein phospholipase A2;serum superoxide dismutases;ischemia modified albumin; | — |
Countries
China
Contacts
Public ContactXiaoyan Su
Outcome results
None listed