Low ejection fraction aortic stenosis
Conditions
Interventions
Treatment group 1:Aortic valve leaf replacement
Treatment group 2:metal valve replacement
Treatment group 3:biological valve replacement
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged at least 18 years; 2. Diagnosis of aortic stenosis, echocardiographic LVEF <50% and dobutamine test for true aortic stenosis; 3. The patient or client agrees to participate in the trial and sign an informed consent form; 4. Compliance is good, willing and able to follow-up observation as required.
Exclusion criteria
Exclusion criteria: 1. Patients who have previously had a heart valve or have had a valve; 2. Patients with other intracardiac malformations or patients requiring coronary artery bypass; 3. Patients with active endocarditis; 4. Patients who participate in other clinical studies at the same time; 5. Drug addicts or alcohol abusers; 6. The patient has severe or progressive cardiovascular or non-cardiovascular disease with a life expectancy of less than 12 months; 7. Pregnant or lactating women; 8. Patients who underwent postoperative anticoagulation according to the guidelines cannot be performed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effective orifice area;mean transprosthetic pressure gradient;Peak flow velocity;Valve regurgitation;Pressure half time reduction;Left heart ejection fraction;Anticoagulant hemorrhagic events;arrhythmia events;endocarditis events,;left ventricular end-diastolic dimension; | — |
Countries
China
Contacts
Public ContactLiu Chao
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed