Breast Cancer
Conditions
Interventions
Group 1:endocrine therapy + supplementary Ca + Guilu Sanhuang
Group 2:endocrine therapy + supplementary Ca
Sponsors
Henan Hospital of Traditional Chinese Medicine (Second Affiliated Hospital of Henan University of Traditional Chinese Medicine)
Eligibility
Sex/Gender
Female
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Histology confirmed breast cancer, according to NCCN guidelines, has indications for adjuvant endocrine therapy; 2. Surgery, adjuvant chemotherapy and/or radiotherapy have been completed; 3. Aged between 30 and 80 years old; 4. Those who have indications of using endocrine therapy and are willing to accept endocrine therapy and are taking endocrine therapy; 5. Bone mineral density (lumbar spine and hip measured by dual-energy X-ray absorptiometry): Osteoporosis was reduced by more than 2.5 standard deviations (T value < 2.5). 6. Those who meet the diagnostic criteria of deficiency of liver and kidney in TCM syndromes; 7. The estimated survival time is more than 6 months.
Exclusion criteria
Exclusion criteria: 1. advanced metastatic breast cancer; 2. Those with poor compliance can not cooperate; 3. Patients who are participating in other drug clinical trials; 4. Those with underlying endocrine disorders without control.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| endocrine;Tumor markers;AKP;PTH;Hyp;COL1A1, COL1A2;TGF-ß1;TGF-ß2;NO, SOD, MDA, GSH-px;IL-1ß, IL-8;TNF-a;OPG;BGP;Color Doppler Ultrasound of Lumbar Spine and Crotch Bone;BMD;Clinical Observation Table of TCM Symptoms;Osteoporosis Score Scale for Breast Cancer after Endocrine Therapy;Quality of Life Scale; | — |
Countries
China
Contacts
Public ContactGUO Qi
Henan Hospital of Traditional Chinese Medicine (Second Affiliated Hospital of Henan University of Traditional Chinese Medicine)
Outcome results
None listed