influenza
Conditions
Interventions
low-dose group:4 Baicalein Tablets and 2 placebo per time, three times a day
high-dose group:6 Baicalein Tablets per time, three times a day
placebo group:6 placebo per time, three times a day
Sponsors
Beijing Chinese Medicine Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for influenza (non-severe); 2. Fever to take medicine for the first time, The patient's maximum temperature (axillary temperature) is over 38?; 3. The rapid virus antigen test of nasal swab was positive; 4. Course of disease = 24 hours(The definition of course of disease is the time from fever to take investigational product for the first time); 5. Aged 18 to 65 years old male and female; 6. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. The patients with severe influenza or complication (e.g. secondary bacterial pneumonia, pneumonia caused by other pathogens or other viral pneumonia); 2. The patients with other acute upper respiratory tract infection (e.g. acute pharyngitis, tonsillitis, rhinitis and nasosinuitis); 3. Allergic to baicalin and its analogue, Paracetamol tablets, or allergic people; 4. Patients with any of the following risk factors: 1) Residents living in long-term care facilities (e.g. welfare house, sanatorium); 2) Combined with chronic respiratory diseases (e.g. bronchial asthma, chronic obstrctive palmonary diseases); 3) Combined with chronic cardiovascular disease (e.g. congenital heart disease, congestive heart failure, or coronary artery disease, but doesnt include hypertension without any other cardio-related symptoms); 4) Combined with hematological system diseases (e.g. chronic myelogenous leukemia, lymphocytic leukemia, myelodysplastic syndrome, aplastic anemia); 5) Neurodevelopmental disorders, include cerebrum, spinal cord, Peripheral nerve and muscle disorders (e.g. cerebral palsy, epilepsy[epileptic seizure disorder], stroke, dysgnosia, Moderate to severe dysplasia, myodystrophy, or spinal cord injury); 6) Poor control of chronic metabolic and endocrine diseases; 7) Immunosuppression (long-term use of immunosuppressant, immunocom promise caused by infection by HIV or malignant tumour); 8) Obese people[BMI>30, BMI=Weight(kg)/Height(m2)]; 5. Long-term take aspirin under 19 years old; 6. White blood cell count>11.0×10^9/L, or the proportion of neutrophils >80%, or need systemic antibacterial therapy; 7. 24 hours before the visit, the patients have received antiviral treatment for influenza; 8. The patients have received Influenza vaccine or research monoclonal antibody in a year; 9. ALT and AST is equal or greater than 1.5 times of upper limit of normal, Scr is greater than upper limit of normal; 10. Suspected or really have a history of alcohol or drug abuse; 11. Gestation (have a positive pregnancy test), lactating women, or have a family planning within the next 6 months; 12. The patients have participated in other clinical trials within 3 months; 13. The investigator considers it inappropriate to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of fever relieving; | — |
Secondary
| Measure | Time frame |
|---|---|
| symptom alleviating time of influenza;Percentage of subjects with influenza complications;Percentage of antipyretic drugs used;Percentage of virus positive to negative; | — |
Countries
China
Contacts
Public ContactQingquan Liu
Beijing Chinese Medicine Hospital affiliated to Capital Medical University
Outcome results
None listed