Virus pneumonia
Conditions
Interventions
Group 2:non-invasive mechanical ventilation
Sponsors
The First Afilliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged >18 years; 2. Diagnosed as acute viral pneumonia, diagnose criteria: (1) Clinical manifestations: fever, cough, headache, muscle pain, or epidemiological history; (2) The pathogen specimen was positive: any one kind of respiratory specimen (nasopharyngeal secretions, sputum, endotracheal aspiration, BALF) is positive: ? nucleic acid of virus; ? virus antigen; ? the virus was isolated from respiratory specimen; ? dynamic detetion of acute phase and recovery phase of serum, virus specific antibody level was 4 times or more increased; 3. Meet one of the following conditions: (1) 150mmHg < P/F < 300mmHg or temporarily do not meet the indications of invasive mechanical ventilation; Detection conditions for arterial blood gas analysis: non-invasive positive pressure ventilation, CPAP mode, CPAP=5cmH2O, adjusting FiO2, and maintaining SPO2 at 88% to 92% for 30 minutes; (2) Patients with initial P/F =150 mmHg, temporary no indications of emergency tracheal intubation, noninvasive positive pressure ventilation support first (based on the experience of doctors set model and parameters, maintaining SPO2 at 88% to 92%) for 4 h, then get arterial blood gas analysis under the condition of CPAP=5cmH2O, 150mmHg < P/F =300mmHg.
Exclusion criteria
Exclusion criteria: 1. Received invasive mechanical ventilation; 2. Underlying diseases and complications: (1) Hypercapnia; (2) Acute attack of bronchial asthma; (3) Acute exacerbation of chronic respiratory failure caused by COPD or other chronic lung diseases; (4) Cardiogenic pulmonary edema; (5) Severe neutropenia (neutrophil < 0.5x10^9 /L); (6) Hemodynamic instability (systolic blood pressure < 90 mmHg or mean arterial pressure < 65 mmHg, vasopressors should be used); (7) GCS score=12; (8) Contraindications to noninvasive ventilation; (9) Indications of emergency endotracheal intubation (evaluated by clinicians); (10) Facial deformities, nasal deformities or diseases cannot receive nasal mask, mask and nasal catheter; (11) Conditions requiring airway protection, such as seizure and massive hemoptysis; 3. Tracheotomy; 4. Refuse endotracheal intubation; 5. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intubation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| time to intubation; | — |
Countries
China
Contacts
Public ContactLiu Xiaoqing
The First Afilliated Hospital of Guangzhou Medical University
Outcome results
None listed